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KMID : 0895820120220010001
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Journal of Oriental Rehabilitation Medicine
2012 Volume.22 No. 1 p.1 ~ p.10
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Acute Toxicity of Fermented Deer Velvet Antler Extract in ICR Mice
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Chung Won-Seok
Kim Sung-Su
Oh Jae-Gueun
Lee Jun-Hwan
Kim Koh-Woon
Park Hyun-Kun
Choi Hyo-Jeong
Lee Jong-Soo
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Abstract
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Objectives :The aim of this study was to investigate the acute toxicity and safety of fermented deer velvet antler extract in institute for cancer research(ICR) mice.
Methods : To evaluate the acute toxicity and safety, fermented deer antler at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg were given orally to 25 male ICR mice for 14 days and allocated 5 mice for each group. After a single administration of fermented deer antler extract, we observed survival rates, general toxicity and any changes in body weight. Autopsies were conducted on all 25 mice.
Results : Compared with the control group, we did not find any toxic alterations in any of the treated groups.
Conclusions : A single dose of 5000 mg/kg of fermented deer antler extract was found to be safe in ICR mice. However, anything beyond this level has the potential to be lethal.
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KEYWORD
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Deer Antler, Fermentation, Acute toxicity, Safety, LD50
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